The huge ethical and scientific problems with the drug Ezetimibe have been discussed widely in the lay press (especially in the New York Times and some excellent reporting in Forbes). The problems have been discussed by patients, on the internet and in the blogsphere. However as of today, a search of our key medical journals reveals no hint of any ethical discussion. No discussion of the principles of good science. Not even a worthy news report. Nothing at all.
- The British medical Journal : No discussion
- The Lancet: On 24 November 2007 in the midst of the saga, the Lancet published a review entitled "The safety of statins in clinical practice" Jane Armitage, Vol. 370, Issue 9601 Pages 1781-1790. There was no relevant discussion or associated editorial in that issue or in any subsequent issue.
- NEJM: No discussion
- JAMA: No discussion
And the multitude was silent, not a voice, not a sound was heard upon the hillsides, across the valleys where they stood.'
Richard Bach, Illusions
One wonders how long our key medical journals will retain any credibility as honest impartial portals for discussion of science and the principles of good medicine. For the record, here is some of the discussion on the top 100 medical blogs
collated in date order. Some have called for a boycott
- 21 Nov 2007 from Your Pharmacist May Hate You: Print Out The Article and Shove It Down The Throat Of your Merck/Schering Rep
- 22 Nov 2007 from PharmaGossip: Is Vytorin about to be renamed Whytorin?
- 24 Nov 2007 from Hooked: Ethics, Medicine, and Pharma: Here We Go Again: Everything That's Wrong with Industry Sponsored Trials
- 24 Nov 2007 from Scientific Misconduct Blog: Ezetimibe (Zetia, Vytorin): the smell of bad science
- 26 November 2007 from Junkfood Science: Even gold can be tarnished
- 26 Nov 2007 from Pharma Marketing Blog: Vytorin Study Stallin' - Notes from the Field Hands
- 26 Nov 2007 from Health Care Renewal: Is it (Clinical) Research, or is it (Pharmaceutical) Marketing? - the ENHANCE Trial of Ezetimibe
- 29 Nov 2007 from MDLinx: ezetimibe: The role of ezetimibe in cholesterol management (evidence-selective article for nurses)
- 22 Dec 2007 from Medical Evidence Blog: Patients and Physicians should BOYCOTT Zetia and Vytorin
- 22 Dec 2007 from Scientific Misconduct Blog: More problems with Ezetimibe (Zetia, Vytorin): Let there be light
- 23 Dec 2007 from Clinical Psychology and Psychiatry: A Closer Look: Changes?
- 24 Dec 2007 from The Healthy Living : Data About Ezetimibe Adverse Effects Suppressed?
- 24 Dec 2007 from Health Care Renewal: Data About Ezetimibe Adverse Effects Suppressed?
- 25 Dec 2007 from Your Pharmacist May Hate You: Merck/Schering don't want You To Know about studies on the liver
- 26 Dec 2007 from Scientific Misconduct Blog: On swearing versus thuggery: a statistical analysis
- 27 Dec 2007 from Your Pharmacist May Hate You: Once Again, The Drugmonkey Gets Results
- 12 Dec 2007 from Pharmalot: Merck & Schering-Plough Backpedal On Vytorin
- 12 Dec 2007 from PharmaGossip: Whytorin Saga contd. - clinical trials, ain't they a bitch!?
- 13 Dec 2007 from Medical Evidence Blog: ENHANCE trial faces congressional scrutiny
- 17 Dec 2007 from Health Care Renewal: Manipulation of ENHANCE Reversed
- 17 Dec 2007 from Pharmalot: Vytorin Researcher Regrets Not Fighting Back
- 18 Dec 2007 from PharmaGossip: ENHANCE your reputation
- 18 Dec 2007 from Dr. Peter Rost: It's never, ever right to change the primary endpoint of a study
- 18 Dec 2007 from PharmaGossip: More on ENHANCE - the case of the shifting endpoint
- 17 Dec 2007 From Pharma Giles: A Doctor's Christmas Carol...some drug reps gave to me, Twelve Zetia Calculators, Eleven Nexium totebags....
- 19 Dec 2007 from Schwitzer Health News Blog: Something smelly about statin trial: Congress investigates
- 21 Dec 2007 from Scientific Misconduct Blog: A ray of light - well done Dr John P. Kastelein
- 21 Dec 2007 from PharmaGossip: Merck/Schering Plough - Zetia: the liver is evil, it must be punished
- 21 Dec 2007 from Clinical Psychology and Psychiatry: A Closer Look: Zetia: But Why Would We Show You the Scary Data?
- 21 Dec 2007 from Pharmalot: How To Find Documents On The FDA Site
- 21 Dec 2007 from Hooked: Ethics, Medicine, and Pharma: New Cholesterol Controversies: Regaining Perspective
- 21 Dec 2007 from Pharmalot: The Vytorin Clock Tells You When To Hide Data
- 21 Dec 2007 from Drug Injury Watch: Cholesterol Drug Zetia May Cause Serious Liver Injury Including Hepatitis And Liver Failure
- 04 Jan 2008 from PharmaGossip: Schering Plough - Zetia/Vytorin: ENHANCE - Listen with Fred
- 05 Jan 2008 from Bad Science: The data belongs to the patients who gave it to you
- 10 Jan 2008 from Scientific Misconduct Blog: The Ezetimibe fiasco - the excuses continue
Labels: BMJ, Ezetimibe, Medical Journals, Merck, Schering-Plough